The Conversion of Shikimic Acid to Anthranilic Acid by Extracts of Neurospora crassa
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The Conversion of Shikimic Acid to Anthranilic Acid by Extracts of Neurospora Crassa.
The role of shikimic acid as a common intermediate in the synthesis of phenylalanine, tyrosine, tryptophan, and p-aminobenzoic acid has been recognized for some time (l-3). The enzymes which catalyze the synthesis of shikimic acid from intermediates of carbohydrate metabolism have been observed in extracts of bacteria (4-6) as well as Neurospora crassa (7). On the other hand, the reactions lead...
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The dihydroxy acid dehydratase of Neurospora crassa was purified lOOto 150-fold by fractionation with protamine sulfate, ammonium sulfate, Sephadex, and DEAE-Sephadex. It was found that the purified protein migrated in an electric field as a single band on acrylamide gel and in the analytical centrifuge. It had a lipid content of 44 to 50%. The enzyme activity was stabilized by the presence of ...
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Avery, 0. T. & Goebel, W. F. (1929). J. exp. Med. 50, 533. Bates, F. J. (1942). Polarimetry, Saccharimetry and the Sugare, pp. 493, 494. Washington, D.C.: United States Government Printing Office. Beiser, S. M., Burke, G. C. & Tanenbaum, S. W. (1960). J. molec. Biol. 2, 125. Fischer, E. (1910). Ber. dtsch. chem. Ge8. 48, 2534. Goebel, W. F., Avery, 0. T. & Babers, F. H. (1934). J. exp. Med. 60,...
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Photosynthetic bacteria and blue-green algae synthesize ornithine from glutamic acid by a cyclic route in which the intermediate N-acetylglutamic acid is regenerated by a transacetylation reaction; furthermore, in these microorganisms, arginine, which is synthesized from ornithine, is a specific inhibitor of N-acetyl-,y-glutamokinase which phosphorylates N-acetylglutamic acid on its y-carboxyl ...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1965
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)97565-4